Ceftriaxone Overview, Dosage, How to Take, Side Effects and Interactions

Ceftriaxone, sold under the trade name Rocephin, is an antibiotic useful for the treatment of a number of bacterial infections. This includes middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. It is also sometimes used before surgery and following a bite wound to try to prevent infection.

Ceftriaxone dosage:

  • Adult: 1–2g IM or IV once daily or in 2 equally divided doses; max 4g/day. Gonorrhea: 250mg IM once. Surgery: a single dose of 1g IV ½–2 hours pre-op.
  • Children: 50–75mg/kg per day in equally divided doses every 12hrs; max 2g/day. Skin and skin structures: may give once daily or in 2 equally divided doses every 12hrs; max 2g/day. Meningitis: 100mg/kg (max 4g) for 1 dose, then 100mg/kg per day (max 4g/day) once daily or in 2 equally divided doses every 12hrs for 7–14 days. Otitis media: 50mg/kg (max 1g) IM once.