Lamotrigine Uses, Dosage, How to Take, Side Effects and Interactions

What is Lamotrigine? Lamotrigine, originally marketed as Lamictal and available under many brands worldwide, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome.

What is the dosage for Lamotrigine?

  • The dose of immediate release Lamotrigine for seizures in patients is 50 mg once daily for two weeks, followed by 100 mg daily given in two divided doses for two weeks. Thereafter, the dose is increased by 100 mg daily every 1-2 weeks up to the usual maintenance dose of 300 to 500 mg daily given as a divided dose.
  • In patients who are taking valproic acid in which it increases blood levels of Lamotrigine, the initial dose of Lamotrigine is 25 mg every other day for two weeks, then 25 mg once daily for two weeks. After 4 weeks the dose is slowly increased by 25 to 50 mg per day every one to two weeks until a dose of 100 to 400 mg once daily or divided twice daily is reached. The maintenance dose when using extended release tablets is 200 to 600 mg once daily.
  • The target dose for treating bipolar disorder is 100 to 400 mg daily.