Rituxan Uses, Dosage, How to Take, Side Effects and Interactions

Rituxan is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Rituxan is used to treat non-Hodgkin’s lymphoma or chronic lymphocytic leukemia. Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis. Rituxan is also used in combination with steroid medicines to treat certain rare disorders that cause inflammation of blood vessels.

What is the dosage for Rituxan?

  • Rituxan is administered by intravenous infusion. Patients should receive acetaminophen (Tylenol) and an antihistamine prior to the infusion to reduce the severity of infusion reactions
  • Patients with rheumatoid arthritis also should receive methylprednisolone┬á (Medrol, Depo-Medrol) 100 mg or a similar drug 30 minutes prior to the infusion to reduce the severity of infusion reactions
  • Non-Hodgkin’s B-cell lymphomas: 375 mg/m2 weekly for 4 to 8 weeks or longer.
  • Chronic lymphocytic leukemia: 375 mg/m2 for the first cycle then 500 mg/m2 every 28 days for cycles 2 to 6
  • Wegener’s granulomatosis or microscopic polyangiitis: 375 mg/m2
  • Rheumatoid arthritis: Two 1000 mg infusions are administered two weeks apart and then are repeated every 16 to 24 weeks