Rituximab Overview, Dosage, How to Take, Side Effects and Precautions

What is Rituximab? Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, idiopathic thrombocytopenic purpura, pemphigus vulgaris and myasthenia gravis. It is given by slow injection into a vein.

Rituximab dosage:

  • The recommended dose of rituximab for the treatment of non-Hodgkin’s lymphoma is 375 mg/m2.
  • The recommended dose of rituximab for the treatment of CLL is 375 mg/m2 in the first cycle and 500 mg/m2 in cycles 2–6, administered every 28 days in combination with fludarabine and cyclophosphamide.
  • The recommended dose of rituximab for the treatment of rheumatoid arthritis in combination with methotrexate is two-1000 mg infusions separated by 2 weeks (one course) every 24 weeks. Methylprednisolone 100 mg intravenous or equivalent glucocorticoid is recommended 30 minutes prior to each infusion.
  • The recommended dose of rituximab for the treatment of granulomatosis with polyangiitis (Wegener’s Granulomatosis) and microscopic polyangiitis in combination with glucocorticoids is 375 mg/m2 once weekly for 4 weeks.