How to take Seroquel. Never take Seroquel in larger amounts, or for longer than recommended by your doctor. Follow all directions on your prescription label. High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements. Take this medicine with a full glass of water. You may take Seroquel with or without food. Do not crush, chew, or break an extended-release tablet. Swallow it whole.