Trintellix Overview, Dosage, How to Take, Side Effects and Precautions

Trintellix is used to treat depression. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain. Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. Trintellix may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

What is the dosage for Trintellix?

  • The recommended starting dose for most adult patients is 10 mg once daily. The dose should then be increased to 20 mg per day as tolerated
  • Since vortioxetine is extensively broken down by a group of liver enzymes known as CYP2D6, patients with reduced activity of these enzymes should not be treated with doses higher than 10 mg/day
  • Although vortioxetine may be discontinued without tapering, manufacturer recommends reducing doses of 15 mg/day or 20 mg/day to 10 mg/day for 1 week prior to discontinuation