Oxcarbazepine interactions. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. A product that may interact with this drug is: orlistat. This medication can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include cobicistat, elvitegravir, certain drugs used to treat chronic hepatitis C (such as simeprevir, sofosbuvir), rilpivirine, among others.